Polyamidoamine Dendrimer Microgels: Hierarchical Arrangement of Dendrimers into Micrometer Domains with Expanded Structural Features for Programmable Drug Delivery and Release

Comparison of generation 3 polyamidoamine dendrimer and generation 4 polypropylenimine dendrimer on drug loading, complex structure, release behavior, and cytotoxicity

BACKGROUND Polyamidoamine (PAMAM) and polypropylenimine (PPI) dendrimers are the commercially available and most widely used dendrimers in pharmaceutical sciences and biomedical engineering. In the present study, the loading and release behaviors of generation 3 PAMAM and generation 4 PPI dendrimers with the same amount of surface amine groups (32 per dendrimer) were compared using phenylbutazo...

Structural studies of biologically active glycosylated polyamidoamine (PAMAM) dendrimers.

The partial modification of carboxylic acid terminated polyamidoamine (PAMAM) dendrimers with glucosamine has been reported to give dendrimer glucosamine conjugates novel immuno-modulatory and anti-angiogenic properties. Experimental analysis of these glycosylated dendrimers showed that, on average, eight glucosamine molecules were covalently bound to each dendrimer. In order to better understa...

Dendrimers: Nanopharmaceuticals for Drug Delivery

Dendrimers are new class of polymeric materials. It is generally described as a macromolecule, which is characterized by its extensively branched 3D structure that provides a high degree of surface functionality and versatility. Dendrimers are highly branched, globular macromolecules with many arms emanating from a central core. The unique properties associated with these dendrimers such as uni...

synthesis and in-vitro characterization of polyamidoamine (pamam) dendrimers nanoparticles for gene delivery

Dendrimer: Globular Nanostructured Materials for Drug Delivery

Nanotechnology is an emerging research field that helps in reviving the structural design, synthesis and fabrication at the molecular magnitude. There are approximately 130 nanopharmaceutical products in development including~nanoparticles, nanocrystals, dendrimers, liposomes and micelles. The increase in the selectivity and stability of therapeutic agents can be achieved with the help of Nanop...